The decision was taken Monday at a meeting held concurrently in all regions.
Ashanti, and the Northern Regions are yet to take any such decision.
Paul Afoko and Kwabena Agyepong, Chairman and General Secretary respectively have been accused of dividing the party.
The mysterious death of the Upper East Regional chairman of the party Adams Mahama, who was attacked with acid appear to have hastened the demand for the resignation of the two.
Even though the two have not been directly connected to the death of the deceased person, critics cite an altercation between Mahama and the two national executives which led to a botched meeting called by the two national executives in the Upper East Region.
The two were conspicuously missing at the funeral and burial of the late Mahama. What was evident was an army of placard-wielding-youth demanding the resignation of the two embattled leaders.
It appears the call by the youth has forced a meeting of regional party executives to begin impeachment processes against the two personnel.
Joy News correspondents in the Eastern, Central and Volta Regions have confirmed that regional executives have passed a vote of no confidence in the two executives.
In the Eastern Region, Edwin Siaw reported that the regional executives have unanimously passed a vote of no confidence in Kwabena Agyepong and Paul Afoko.
The reason for the decision is that if they should retain the two, they might possibly lose northern votes because of the murdered chairman in the Upper East Region.
Out of 26 Minority MPs in the Eastern Region only four were present. 28 Constituency Chairmen out of 33 were also present.
In the Central Region, Richard Kojo Nyarko has also confirmed the executives’ decision to pass a vote of no confidence in the two executives.
Central Region Secretary Kwamena Duncan confirmed the report.
In the Volta Region, Ivy Setordjie has also confirmed the decision by the party’s regional executives to pass a vote of no confidence in the two.
Regional executives in the Ashanti Region have resisted the decision to have the two executives impeached.
A meeting called to consider a possible impeachment process ended inconclusively with some executives insisting they have no right to impeach anybody.
Frederick Fredua Antoh a national executive and former chair in the Ashanti Region is unhappy about the decision.
The Upper East, West and Northern Regions are yet to make a decision on the fate of the two embattled executives.
Per the party’s constitution, at least 40 per cent of the delegates must submit a vote of no confidence for the impeachment process of any executive to begin.